Human basophils may not undergo modulation by DC-SIGN and mannose receptor–targeting immunotherapies due to absence of receptors - Sorbonne Université
Journal Articles Journal of Allergy and Clinical Immunology Year : 2017

Human basophils may not undergo modulation by DC-SIGN and mannose receptor–targeting immunotherapies due to absence of receptors

Abstract

Sirvent et al1 recently showed that novel vaccines targeting dendritic cells (DCs) by coupling glutaraldehyde-polymerized grass pollen allergoids to nonoxidized mannan enhance allergen uptake and induce functional regulatory T cells through programmed death ligand 1. Mechanistically, they found that nonoxidized mannan-coupled glutaraldehyde-polymerized grass pollen allergoids are captured and internalized by 2 lectin receptors on DCs: mannose receptor (CD206) and DC-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN or CD209). These data thus indicated that DCs could be targeted by C-type lectin receptors for efficient allergen immunotherapy.

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Immunology
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Dates and versions

inserm-02455463 , version 2 (25-01-2017)
inserm-02455463 , version 1 (26-01-2020)

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Mrinmoy Das, Caroline Galeotti, Emmanuel Stephen-Victor, Anupama Karnam, Srini V. Kaveri, et al.. Human basophils may not undergo modulation by DC-SIGN and mannose receptor–targeting immunotherapies due to absence of receptors. Journal of Allergy and Clinical Immunology, 2017, 139 (4), pp.1403-1404.e1. ⟨10.1016/j.jaci.2016.09.062⟩. ⟨inserm-02455463v2⟩
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