Water isotopes-climate correlations are used to reconstruct paleoclimate from various natural archives. Intra-seasonal oscillation is one of the major atmospheric patterns that modulate the ratio of precipitation isotope in low latitudes, yet their spatial and temporal distribution patterns are unclear. Here we presented a detailed analysis of how the intra-seasonal oscillations (MJO, Madden-Julian Oscillation, and BSISO, Boreal Summer Intra-seasonal Oscillation) modulate precipitation δ¹⁸O and vapor δ¹⁸O over the Asian monsoon region and the equatorial region. This analysis found consistent intra-seasonal variations between the ISO and rain δ¹⁸O. We interpret it as the ISO regulating the active and inactive convective systems on the regional scale, leading to the intra-seasonal oscillations in precipitation δ¹⁸O, with amplitudes from 4‰ up to 15‰. The MJO (BSISO) leads to eastward (northeastward) propagation of δ¹⁸O intra-seasonal oscillations in the Asian equatorial (monsoon) region, coinciding with the spatial patterns of OLR oscillations, reflecting the response of precipitation/vapor δ¹⁸O to the oscillation of large-scale convective activity or accumulated depletion of regional precipitation. We proved that the amplitudes of intra-seasonal variation of precipitation δ¹⁸O are comparable to seasonal variations, and both of them are the main patterns for precipitation δ¹⁸O in study regions. Our results are conducive to the accurate interpretation of δ¹⁸O in climate proxies such as precipitation, ice cores, tree cellulose, cave stalagmites, et al. on the intra-seasonal scale in this region.