Dynamic full-field optical coherence tomography as complementary tool in fungal diagnostics - Sorbonne Université
Article Dans Une Revue Journal of Medical Mycology = Journal de Mycologie Médicale Année : 2022

Dynamic full-field optical coherence tomography as complementary tool in fungal diagnostics

Résumé

Histopathology and microscopic examination of infected tissue are the gold standards to prove the diagnosis of invasive fungal infection (IFI). Yet, they suffer from essential limitations that hamper rapid diagnosis and require the future development of new imaging tools dedicated to fungal diagnostics. To this end, the present work introduces the first use of dynamic full-field optical coherence tomography (D-FF-OCT) for the visualization of microscopic filamentous fungi. Data collected from the observation of three different fungal species (Nannizzia gypsea, Aspergillus fumigatus and Rhizopus arrhizus) confirm the ability of D-FF-OCT to visualize not only the main structures of all selected fungal species (hyphae, spores, conidia, sporulating structures), but also the metabolic activity of the organisms, which could provide additional help in the future to better characterize the signature of each fungal structure. These results demonstrate how D-FF-OCT could serve as potential complementary tool for rapid diagnosis of IFI in both intensive and non-intensive care units.
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pasteur-04173114 , version 1 (22-07-2024)

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Thomas Maldiney, Jean-Marie Chassot, Claude Boccara, Mathieu Blot, Lionel Piroth, et al.. Dynamic full-field optical coherence tomography as complementary tool in fungal diagnostics. Journal of Medical Mycology = Journal de Mycologie Médicale, 2022, 32 (4), pp.101303. ⟨10.1016/j.mycmed.2022.101303⟩. ⟨pasteur-04173114⟩
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