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Journal Articles Expert Review of Vaccines Year : 2007

The complex link between immunization against childhood diseases and allergy.

Abstract

Vaccines can be at the origin of allergic manifestations in susceptible children. Such manifestations include: immediate-type hypersensitivity (anaphylactic shock, rash or angioedema) within 1 h after the injection; semi-late hypersensitivity (local inflammatory lesion such as the Arthus phenomenon) a few hours after the injection; and delayed-type hypersensitivity (abscess or eczema at the site of the injection). Furthermore, early-life vaccinations have been implicated in the modulation of the immune system as they could promote the development of allergy by avoiding infections. However, most population-based studies have not found an increased risk of allergies in vaccinated children. Due to methodological problems in conducting the studies, further investigations are needed to better understand the phenomenon.
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hal-00595697 , version 1 (25-05-2011)

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Sofia Kalaboka, Isabella Annesi-Maesano. The complex link between immunization against childhood diseases and allergy.. Expert Review of Vaccines, 2007, 6 (4), pp.635-43. ⟨10.1586/14760584.6.4.635⟩. ⟨hal-00595697⟩
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