Economic impact of gefitinib for refractory non-small-cell lung cancer: a Markov model-based analysis. - Sorbonne Université Access content directly
Journal Articles Current Medical Research and Opinion Year : 2007

Economic impact of gefitinib for refractory non-small-cell lung cancer: a Markov model-based analysis.

Abstract

UNLABELLED: Few data are available on the economics of target therapy or refractory non-small-cell lung cancer (NSCLC). OBJECTIVE: To determine the mean global management costs (MC) per patient treated with gefitinib for NSCLC, and the costs of the different management phases. METHOD: A Markov approach was used to model treatment costs in a cohort of 106 patients treated with gefitinib as part of a compassionate-use program (third-line treatment) in six public-sector teaching hospitals. The economic analysis adopted the health care payer's perspective, and only direct costs were taken into account. RESULTS: The mean duration of gefitinib treatment was 4.6 +/- 5.8 months (1-29 months); median survival was 4 months, 1-year and 2-year survival rates were 12.3% and 4.7%, respectively. The mean total management cost was 39,979 euros +/- 20,279. The model showed that first- and second-line treatments accounted for respectively 29.5% and 44.1% of this cost, while gefitinib periods represented 10.7%, periods of remission 1.25%, and terminal care 14.5%. A sensitivity analysis showed that the price of gefitinib had little influence on the total cost. CONCLUSION: The cost of third-line gefitinib therapy for NSCLC appears acceptable from the healthcare payer's perspective, but this needs to be confirmed in dedicated cost-effectiveness studies.
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Dates and versions

hal-00597106 , version 1 (31-05-2011)

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Christos Chouaid, Isabelle Monnet, Gilles Robinet, Maurice Perol, Pierre Fournel, et al.. Economic impact of gefitinib for refractory non-small-cell lung cancer: a Markov model-based analysis.. Current Medical Research and Opinion, 2007, 23 (7), pp.1509-15. ⟨10.1185/030079907X199718⟩. ⟨hal-00597106⟩
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