Modulation of arachidonic acid metabolism and cyclic AMP content of human alveolar macrophages. - Sorbonne Université Access content directly
Journal Articles Eicosanoids Year : 1992

Modulation of arachidonic acid metabolism and cyclic AMP content of human alveolar macrophages.

M. Bachelet
  • Function : Author
N. Havet
A. Barre
  • Function : Author
B. Housset
  • Function : Author
B. B. Vargaftig
  • Function : Author

Abstract

The exposure of human alveolar macrophages to inflammatory mediators such as PAF (1 microM), fMLP (1 microM) or the calcium ionophore A23187 (1 microM) induced a rapid decrease in their intracellular concentration of cAMP. Inhibition of TXA2 synthesis by the specific thromboxane synthase inhibitor ridogrel (1-10 microM) or by non-specific inhibitors as indomethacin (1-10 microM), the cyclooxygenase inhibitor, or BW A4C (1-10 microM), the 5-lipoxygenase inhibitor, partially prevented the decrease in cAMP induced by the different inflammatory stimuli. Evidence for an indirect control of cAMP levels in human alveolar macrophages by inflammatory mediators through the production of arachidonic acid derivatives from the cyclooxygenase pathway is supported by this study.
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Dates and versions

hal-00597530 , version 1 (01-06-2011)

Identifiers

  • HAL Id : hal-00597530 , version 1
  • PUBMED : 1337976

Cite

M. Bachelet, C. Chouaid, N. Havet, J. Masliah, A. Barre, et al.. Modulation of arachidonic acid metabolism and cyclic AMP content of human alveolar macrophages.. Eicosanoids, 1992, 5 (3-4), pp.185-90. ⟨hal-00597530⟩
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