In this paper, we consider reaction-diffusion-advection equations in slowly periodi-cally oscillating media. We prove the existence of and we give explicit expressions of the asymptotic spreading speeds of invasion of the unstable state 0 in any direction, when the period of the invaded medium becomes infinitely large. The limiting sprea-ding speeds involve families of 1-periodic Hamilton-Jacobi equations. In the case of one-dimensional reaction-diffusion equations, we analyze the relative effects of small perturbations of the diffusion and the reaction coefficients, and we compare the spreading speeds in slowly oscillating media to the homogenized spreading speeds in rapidly oscillating media.