The Physarum polycephalum Genome Reveals Extensive Use of Prokaryotic Two-component and Metazoan-type Tyrosine Kinase Signaling
Pauline Schaap
(1)
,
Israel Barrantes
(2)
,
Pat Minx
(3)
,
Narie Sasaki
(4)
,
Roger W. Anderson
(5)
,
Marianne Bénard
(6)
,
Kyle K. Biggar
(7)
,
Nicolas E. Buchler
(8)
,
Ralf Bundschuh
(9)
,
Xiao Chen
(10)
,
Catrina Fronick
(3)
,
Lucinda Fulton
(3)
,
Georg Golderer
(11)
,
Niels Jahn
(12)
,
Volker Knoop
(13)
,
Laura F. Landweber
(10)
,
Chrystelle Maric
(14)
,
Dennis Miller
(15)
,
Angelika A Noegel
(16)
,
Rob Peace
(17)
,
Gérard Pierron
(14)
,
Taeko Sasaki
(4)
,
Mareike Schallenberg-Rüdinger
(13)
,
Michael Schleicher
(18)
,
Reema Singh
(1)
,
Thomas Spaller
(19)
,
Kenneth B. Storey
(17)
,
Takamasa Suzuki
(4)
,
Chad Tomlinson
(3)
,
John J. Tyson
(20)
,
Wesley C. Warren
(3)
,
Ernst R. Werner
(11)
,
Gabriele Werner-Felmayer
(11)
,
Richard K. Wilson
(3)
,
Thomas Winckler
(19)
,
Jonatha M. Gott
(21)
,
Gernot Glöckner
(22, 16)
,
Wolfgang Marwan
(2)
1
University of Dundee
2 OVGU - Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg]
3 Washington University School of Medicine [Saint Louis, MO]
4 NAGOYA - Nagoya
5 University of Sheffield [Sheffield]
6 LBD - Laboratoire de Biologie du Développement
7 UWO - University of Western Ontario
8 Duke University [Durham]
9 OSU - Ohio State University [Columbus]
10 Princeton University
11 Universität Innsbruck [Innsbruck]
12 Fritz Lipmann Institute
13 Rheinische Friedrich-Wilhelms-Universität Bonn
14 IJM (UMR_7592) - Institut Jacques Monod
15 UT Dallas - University of Texas at Dallas [Richardson]
16 University of Cologne
17 Carleton University
18 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
19 Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany]
20 Virginia Polytechnic Institute and State University [Blacksburg]
21 Case Western Reserve University [Cleveland]
22 IGB - Leibniz-Institut für Gewässerökologie und Binnenfischerei
2 OVGU - Otto-von-Guericke-Universität Magdeburg = Otto-von-Guericke University [Magdeburg]
3 Washington University School of Medicine [Saint Louis, MO]
4 NAGOYA - Nagoya
5 University of Sheffield [Sheffield]
6 LBD - Laboratoire de Biologie du Développement
7 UWO - University of Western Ontario
8 Duke University [Durham]
9 OSU - Ohio State University [Columbus]
10 Princeton University
11 Universität Innsbruck [Innsbruck]
12 Fritz Lipmann Institute
13 Rheinische Friedrich-Wilhelms-Universität Bonn
14 IJM (UMR_7592) - Institut Jacques Monod
15 UT Dallas - University of Texas at Dallas [Richardson]
16 University of Cologne
17 Carleton University
18 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
19 Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany]
20 Virginia Polytechnic Institute and State University [Blacksburg]
21 Case Western Reserve University [Cleveland]
22 IGB - Leibniz-Institut für Gewässerökologie und Binnenfischerei
Chrystelle Maric
- Fonction : Auteur
- PersonId : 179298
- IdHAL : chrystelle-maric-antoinat
- ORCID : 0000-0002-6735-1441
Résumé
To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10−8), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
Domaines
Sciences du Vivant [q-bio]
Origine : Publication financée par une institution
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