Genome-wide association study identifies multiple susceptibility loci for glioma
Ben Kinnersley
(1)
,
Marianne Labussière
(2)
,
Amy Holroyd
(3)
,
Anna-Luisa Di Stefano
(4, 2, 5)
,
Peter Broderick
(6)
,
Jayaram Vijayakrishnan
,
Karima Mokhtari
(7)
,
Jean-Yves Delattre
(4, 2)
,
Konstantinos Gousias
(8)
,
Johannes Schramm
(8)
,
Minouk J. Schoemaker
,
Sarah J. Fleming
,
Stefan Herms
(9)
,
Stefanie Heilmann
(10)
,
Stefan Schreiber
(11)
,
Heinz-Erich Wichmann
(12, 13, 14)
,
Markus M. Nöthen
(15)
,
Anthony Swerdlow
,
Mark Lathrop
(16, 17)
,
Matthias Simon
(18)
,
Melissa Bondy
(19)
,
Marc Sanson
(2, 4, 4)
,
Richard S. Houlston
(20)
1
The Institute of Cancer Research
2 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
3 Microsoft Research [Redmond]
4 CHU Pitié-Salpêtrière [AP-HP]
5 Fondazione "Istituto Neurologico Nazionale C. Mondino"
6 Division of genetics and epidemiology
7 Laboratoire de Neuropathologie Raymond Escourolle [CHU Pitié-Salpétriêre]
8 University of Bonn Medical Center
9 Department of Genomics
10 Institute of Human Genetics [Erlangen, Allemagne]
11 CAU - Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
12 Helmholtz Zentrum München = German Research Center for Environmental Health
13 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
14 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
15 Rheinische Friedrich-Wilhelms-Universität Bonn
16 Fondation Jean Dausset CEPH
17 McGill University = Université McGill [Montréal, Canada]
18 LCPMR - Laboratoire de Chimie Physique - Matière et Rayonnement
19 BCM - Baylor College of Medicine
20 Institute of Cancer Research, Belmont, Sutton
2 ICM - Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute
3 Microsoft Research [Redmond]
4 CHU Pitié-Salpêtrière [AP-HP]
5 Fondazione "Istituto Neurologico Nazionale C. Mondino"
6 Division of genetics and epidemiology
7 Laboratoire de Neuropathologie Raymond Escourolle [CHU Pitié-Salpétriêre]
8 University of Bonn Medical Center
9 Department of Genomics
10 Institute of Human Genetics [Erlangen, Allemagne]
11 CAU - Christian-Albrechts-Universität zu Kiel = Christian-Albrechts University of Kiel = Université Christian-Albrechts de Kiel
12 Helmholtz Zentrum München = German Research Center for Environmental Health
13 LMU - Ludwig Maximilian University [Munich] = Ludwig Maximilians Universität München
14 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
15 Rheinische Friedrich-Wilhelms-Universität Bonn
16 Fondation Jean Dausset CEPH
17 McGill University = Université McGill [Montréal, Canada]
18 LCPMR - Laboratoire de Chimie Physique - Matière et Rayonnement
19 BCM - Baylor College of Medicine
20 Institute of Cancer Research, Belmont, Sutton
Jayaram Vijayakrishnan
- Function : Author
Minouk J. Schoemaker
- Function : Author
Sarah J. Fleming
- Function : Author
Anthony Swerdlow
- Function : Author
Marc Sanson
- Function : Author
- PersonId : 760119
- ORCID : 0000-0002-1813-8476
Abstract
Previous genome-wide association studies (GWASs) have shown that common genetic variation contributes to the heritable risk of glioma. To identify new glioma susceptibility loci, we conducted a meta-analysis of four GWAS (totalling 4,147 cases and 7,435 controls), with imputation using 1000 Genomes and UK10K Project data as reference. After genotyping an additional 1,490 cases and 1,723 controls we identify new risk loci for glioblastoma (GBM) at 12q23.33 (rs3851634, near POLR3B, P=3.02 × 10−9) and non-GBM at 10q25.2 (rs11196067, near VTI1A, P=4.32 × 10−8), 11q23.2 (rs648044, near ZBTB16, P=6.26 × 10−11), 12q21.2 (rs12230172, P=7.53 × 10−11) and 15q24.2 (rs1801591, near ETFA, P=5.71 × 10−9). Our findings provide further insights into the genetic basis of the different glioma subtypes.