Novel variation at chr11p13 associated with cystic fibrosis lung disease severity - Sorbonne Université
Journal Articles Human Genome Variation Year : 2016

Novel variation at chr11p13 associated with cystic fibrosis lung disease severity

Abstract

Published genome-wide association studies (GWASs) identified an intergenic region with regulatory features on chr11p13 associated with cystic fibrosis (CF) lung disease severity. Targeted resequencing in n=377, followed by imputation to n=6,365 CF subjects, was used to identify unrecognized genetic variants (including indels and microsatellite repeats) associated with phenotype. Highly significant associations were in strong linkage disequilibrium and were seen only in Phe508del homozygous CF subjects, indicating a CFTR genotype-specific mechanism.
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Dates and versions

hal-01359027 , version 1 (15-07-2024)

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Hong Dang, Paul J Gallins, Rhonda G Pace, Xue-Liang Guo, Jaclyn R Stonebraker, et al.. Novel variation at chr11p13 associated with cystic fibrosis lung disease severity. Human Genome Variation, 2016, 3, pp.16020. ⟨10.1038/hgv.2016.20⟩. ⟨hal-01359027⟩
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