Novel variation at chr11p13 associated with cystic fibrosis lung disease severity - Sorbonne Université
Article Dans Une Revue Human Genome Variation Année : 2016

Novel variation at chr11p13 associated with cystic fibrosis lung disease severity

Résumé

Published genome-wide association studies (GWASs) identified an intergenic region with regulatory features on chr11p13 associated with cystic fibrosis (CF) lung disease severity. Targeted resequencing in n=377, followed by imputation to n=6,365 CF subjects, was used to identify unrecognized genetic variants (including indels and microsatellite repeats) associated with phenotype. Highly significant associations were in strong linkage disequilibrium and were seen only in Phe508del homozygous CF subjects, indicating a CFTR genotype-specific mechanism.
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Dates et versions

hal-01359027 , version 1 (15-07-2024)

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Citer

Hong Dang, Paul J Gallins, Rhonda G Pace, Xue-Liang Guo, Jaclyn R Stonebraker, et al.. Novel variation at chr11p13 associated with cystic fibrosis lung disease severity. Human Genome Variation, 2016, 3, pp.16020. ⟨10.1038/hgv.2016.20⟩. ⟨hal-01359027⟩
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