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Cubic three-dimensional hybrid silica solids for nuclear hyperpolarization

Abstract : Hyperpolarization of metabolites by dissolution dynamic nuclear polarization (D-DNP) for MRI applications often requires fast and efficient removal of the radicals (polarizing agents). Ordered mesoporous SBA-15 silica materials containing homogeneously dispersed radicals, referred to as HYperPolarizing SOlids (HYPSOs), enable high polarization – P(1H) = 50% at 1.2 K – and straightforward separation of the polarizing HYPSO material from the hyperpolarized solution by filtration. However, the one-dimensional tubular pores of SBA-15 type materials are not ideal for nuclear spin diffusion, which may limit efficient polarization. Here, we develop a generation of hyperpolarizing solids based on a SBA-16 structure with a network of pores interconnected in three dimensions, which allows a significant increase of polarization, i.e. P(1H) = 63% at 1.2 K. This result illustrates how one can improve materials by combining a control of the incorporation of radicals with a better design of the porous network structures.
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Submitted on : Tuesday, September 6, 2016 - 2:20:44 PM
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D Baudouin, Henri A van Kalkeren, A Bornet, B Vuichoud, L Veyre, et al.. Cubic three-dimensional hybrid silica solids for nuclear hyperpolarization . Chemical Science , The Royal Society of Chemistry, 2016, 7 (11), pp.6846-6850 ⟨10.1039/c6sc02055k⟩. ⟨hal-01360905⟩

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