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La place de la physicochimie en urologie et en néphrologie : le bilan de 10ans de collaboration entre physiciens, chimistes et praticiens hospitaliers

Abstract : Introduction: The presence of pathological calcifications, which can be either concretions or ectopic call for physicochemical characterisation techniques in order to define a significant diagnosis. The aim of this review is to present a set of characterisation techniques able to describe at the micrometer scale their structural and chemical characteristics and show their place at the hospital. Method: Results already published in the last ten years based on characterisation techniques present in laboratories or specific to large-scale instruments are presented. Their usefulness for the clinician is discussed. Results: The presence and role of heavy metals in urinary stones through data collected through μX-ray fluorescence is debated. If these data suggest a simple substitution process of calcium, recent data suggest that weddellite is associated to a Zn-rich environment, partly favoured by an inflammation process. Investigation on the chemistry and the structure of unusual deposits in kidney biopsies show a great chemical diversity of ectopic calcifications. Such diversity shows that staining procedures to characterize such deposits are obsolete. Finally, several diseases which can be assessed through techniques specific to large-scale instruments and defined by the clinician are presented. Conclusion: The chemical and structural complexity of pathological calcifications call for a characterization through physicochemical techniques. Only such approach allows the clinician to define a significant diagnosis and to care the patient.
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Submitted on : Monday, September 26, 2016 - 4:19:06 PM
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Dominique Bazin, Emmanuel Letavernier, J.-P. Haymann, P. Méria, Michel Daudon. La place de la physicochimie en urologie et en néphrologie : le bilan de 10ans de collaboration entre physiciens, chimistes et praticiens hospitaliers. Progrès en Urologie, Elsevier Masson, 2016, 26 (11-12), pp.608-618. ⟨10.1016/j.purol.2016.08.019⟩. ⟨hal-01371949⟩

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