Development of a Cradle-to-Grave Approach for Acetylated Acidic Sophorolipid Biosurfactants

Niki Baccile; Florence Babonneau; Ibrahim M. Banat; Katarzyna Ciesielska; Anne-Sophie Cuvier; Bart Devreese; Bernd Everaert; Helen Lydon; Roger Marchant; Christopher A. Mitchell; Sophie Roelants; Lasse Six; Elke Theeuwes; Georgios Tsatsos; Georgia Eleni Tsotsou; Brecht Vanlerberghe; Inge N. A. van Bogaert; Wim Soetaert

doi:10.1021/acssuschemeng.6b02570

Journal articles

Development of a Cradle-to-Grave Approach for Acetylated Acidic Sophorolipid Biosurfactants

Niki Baccile ^{1, *} Florence Babonneau ¹ Ibrahim M. Banat ² Katarzyna Ciesielska ³ Anne-Sophie Cuvier ¹ Bart Devreese ³ Bernd Everaert ⁴ Helen Lydon ² Roger Marchant ² Christopher A. Mitchell ² Sophie Roelants ^{5, 4} Lasse Six ⁶ Elke Theeuwes ⁷ Georgios Tsatsos ⁸ Georgia Eleni Tsotsou ⁸ Brecht Vanlerberghe ⁴ Inge N. A. van Bogaert ⁵ Wim Soetaert ^{4, 5, *}

* Corresponding author

1 SMiLES - Spectroscopie, Modélisation, Interfaces pour L'Environnement et la Santé

LCMCP - Laboratoire de Chimie de la Matière Condensée de Paris

2 University of Ulster

3 Laboratory for Protein Biochemistry and Biomolecular Engineering, Department of Biochemistry, Physiology and Microbiology

4 Bio Base Europe Pilot Plant

5 Faculty of Bioscience Engineering, Ghent University

6 OWS - Organic Waste Systems

7 Ecover Co-ordination Center NV

8 COSMETIC SP

Abstract : Microbial production of biosurfactants represents one of the most interesting alternatives to classical petrol-based compounds due to their low toxicity, high biodegradability, and biological production processes from renewable bioresources. However, some of the main drawbacks generally encountered are the low productivities and the small number of chemical structures available, which limit widespread application of biosurfactants. Although chemical derivatization of (microbial) biosurfactants offers opportunities to broaden the panel of available molecules, direct microbial synthesis is still the preferred option and the use of engineered strains is becoming a valid alternative. In this multidisciplinary work we show the entire process of conception, upscaling of fermentation (150 L) and sustainable purification (filtration), application (foaming, solubilization, antibacterial), and life cycle analysis of acetylated acidic sophorolipids, directly produced by the Starmerella bombicola esterase knock out yeast strain, rather than purified using chromatography from the classical, but complex, mixture of acidic and lactonic sophorolipids.

Keywords : Glycolipids Life cycle analysis Self-assembly Starmerella bombicola Antimicrobial Genetic engineering

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Journal articles

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Chemical Sciences

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