Tantalum-containing SiBEA zeolite with isolated framework mononuclear Ta(V) doped with Ag, Cu and Zn were prepared and characterized by XRD, XPS, DR UV-VIS and FTIR (with pyridine, 2,6-di-tert-butylpyridine, pyrrole and deuterated chloroform). The conversion of ethanol as renewable raw material into 1,3-butadiene by Lebedev method over these zeolite catalysts was investigated. The doping of TaSiBEA with Ag, Cu and Zn changes its catalytic properties in ethanol conversion into 1,3-butadiene as a result of modification of acid-base properties with formation of additional dehydrogenation sites. Such modification allows accelerating ethanol dehydrogenation to acetaldehyde and subsequent steps of the ethanol-to-butadiene process. Ethanol conversion and butadiene selectivity over the catalysts increase in the order: TaSiBEA < ZnTaSiBEA < AgTaSiBEA < CuTaSiBEA. Higher selectivity to butadiene (73 %) was achieved over CuTaSiBEA (at 88% ethanol conversion, T = 598 К, WHSV = 0.5 h-1).