Diabetes remission after bariatric surgery in obese patients with haemochromatosis
Résumé
Haemochromatosis represents a common autosomal-recessive hereditary disease that induces iron overload [1]. The most frequent mutation results in a change of cysteine to tyrosine at position 282 (C282Y) in the HFE protein. HFE is required for stimulation of hepcidin, which acts as a regulator of iron intestinal absorption. When mutated, hepcidin is decreased while iron absorption remains inappropriately high, even when iron body stores are replete [2] Haem iron is found in red meat, specifically in haemoprotein. After ingestion, iron is released from haem secondary to lowering of stomach pH and its enzymes. Most of the iron absorption happens in the duodenum and proximal jejunum.
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