The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity

Abstract : Ferroptosis is a form of regulated cell death that may facilitate the selective elimination of tumor cells. The tumor suppressor p53 (TP53) has been demonstrated to promote ferroptosis via a transcription-dependent mechanism. Here, we show that TP53 limits erastin-induced ferroptosis by blocking dipeptidyl-peptidase-4 (DPP4) activity in a transcription-independent manner. Loss of TP53 prevents nuclear accumulation of DPP4 and thus facilitates plasma-membrane-associated DPP4-dependent lipid peroxidation, which finally results in ferroptosis. These findings reveal a direct molecular link between TP53 and DPP4 in the control of lipid metabolism and may provide a precision medicine strategy for the treatment of colorectal cancer by induction of ferroptosis.
Type de document :
Article dans une revue
Cell Reports , Elsevier Inc, 2017, 20 (7), pp.1692-1704. 〈10.1016/j.celrep.2017.07.055〉
Liste complète des métadonnées

Littérature citée [63 références]  Voir  Masquer  Télécharger

https://hal.sorbonne-universite.fr/hal-01581142
Contributeur : Gestionnaire Hal-Upmc <>
Soumis le : lundi 4 septembre 2017 - 13:33:22
Dernière modification le : mercredi 28 mars 2018 - 13:16:01

Fichier

1-s2.0-S2211124717310343-main....
Publication financée par une institution

Licence


Distributed under a Creative Commons Paternité 4.0 International License

Identifiants

Citation

Yangchun Xie, Shan Zhu, Xinxin Song, Xiaofang Sun, Yong Fan, et al.. The Tumor Suppressor p53 Limits Ferroptosis by Blocking DPP4 Activity. Cell Reports , Elsevier Inc, 2017, 20 (7), pp.1692-1704. 〈10.1016/j.celrep.2017.07.055〉. 〈hal-01581142〉

Partager

Métriques

Consultations de la notice

413

Téléchargements de fichiers

83