Scalable 9-Step Synthesis of the Splicing Modulator NVS-SM2
Résumé
NVS-SM2, the first activator of pre-mRNA splicing, displays remarkable pharmacological in vivo activities in models of spinal muscular atrophy. Herein we describe an improved approach to the synthesis of this compound, which features a convenient introduction of sterically encumbered amine moiety onto a fluoropyridazine intermediate.
Origine : Fichiers produits par l'(les) auteur(s)
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