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Journal Articles Journal of Organic Chemistry Year : 2018

Scalable 9-Step Synthesis of the Splicing Modulator NVS-SM2

Laurent Désaubry

Abstract

NVS-SM2, the first activator of pre-mRNA splicing, displays remarkable pharmacological in vivo activities in models of spinal muscular atrophy. Herein we describe an improved approach to the synthesis of this compound, which features a convenient introduction of sterically encumbered amine moiety onto a fluoropyridazine intermediate.
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Dates and versions

hal-01830554 , version 1 (05-07-2018)

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Hussein Abou-Hamdan, Laurent Désaubry. Scalable 9-Step Synthesis of the Splicing Modulator NVS-SM2. Journal of Organic Chemistry, 2018, 83 (5), pp.2954-2958. ⟨10.1021/acs.joc.7b03009⟩. ⟨hal-01830554⟩
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