Graftable SCoMPIs enable the labeling and X-ray fluorescence imaging of proteins
Résumé
Bio-imaging techniques alternative to fluorescence microscopy are gaining increasing interest as complementary tools to visualize and analyze biological systems. Among them, X-ray fluorescence microspectroscopy provides information on the local content and distribution of heavy elements (Z ≥ 14) in cells or biological samples. In this context, similar tools to those developed for fluorescence microscopy are desired, including chemical probes or tags. In this work, we study rhenium complexes as a convenient and sensitive probe for X-ray fluorescence microspectroscopy. We demonstrate their ability to label and sense exogenously incubated or endogenous proteins inside cells.
Domaines
Biologie structurale [q-bio.BM]
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c8sc00886h.pdf (527.86 Ko)
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Hostachy18ChemSci-HD-HDNLS-Xfluorescence-SI-c8sc00886h.pdf (4.49 Mo)
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Origine : Publication financée par une institution
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