Emerging evidence for the modulation of exocytosis by signalling lipids

Abstract : Membrane fusion is a key event in exocytosis of neurotransmitters and hormones stored in intracellular vesicles. In this process, soluble N‐ethylmaleimide sensitive factor attachment protein receptor (SNARE) proteins are essential components of the exocytotic molecular machinery, while lipids have been seen traditionally as structural elements. However, the so‐called signalling lipids, such as sphingosine and arachidonic acid, interact with SNAREs and directly modulate the frequency and mode of fusion events. Interestingly, recent work has proved that the sphingosine analogue FTY‐720, used in the treatment of multiple sclerosis, mimics the effects of signalling lipids. In the present Review, we discuss recent investigations suggesting that endogenous signalling lipids and synthetic analogues can modulate important physiological aspects of secretion, such as quantal release, vesicle recruitment into active sites, vesicle transport and even organelle fusion in the cytosol. Therefore, these compounds are far from being merely structural components of cellular membranes.
Document type :
Journal articles
Complete list of metadatas

https://hal.sorbonne-universite.fr/hal-01935292
Contributor : Gestionnaire Hal-Upmc <>
Submitted on : Monday, November 26, 2018 - 3:47:57 PM
Last modification on : Tuesday, April 2, 2019 - 2:00:46 AM
Long-term archiving on : Wednesday, February 27, 2019 - 3:03:42 PM

File

Garcia-Martinez_et_al-2018-FEB...
Publication funded by an institution

Licence


Distributed under a Creative Commons Attribution 4.0 International License

Identifiers

Citation

Virginia García-Martinez, Yolanda Gimenez-Molina, José Villanueva, Frédéric Darios, Bazbek Davletov, et al.. Emerging evidence for the modulation of exocytosis by signalling lipids. FEBS Letters, Wiley, 2018, 592 (21), pp.3493 - 3503. ⟨10.1002/1873-3468.13178⟩. ⟨hal-01935292⟩

Share

Metrics

Record views

43

Files downloads

83