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Journal Articles European Journal of Inorganic Chemistry Year : 2020

Bioorthogonal Conjugation of Transition Organometallic Complexes to Peptides and Proteins: Strategies and Applications

Abstract

The advent of bioorthogonal chemistry has revolutionized the common practices in protein bioconjugation and contributed to a large extent to the development of chemical biology, a discipline aimed at studying biological/biochemical processes/events in their natural setting (living cells, whole organisms) using dedicated chemical tools. This minireview intends to provide an up‐to‐date overview on the various bioorthogonal strategies implemented for the conjugation of transition organometallic entities to peptides, peptide nucleic acids and proteins with a focus on targeted applications, i.e. fluorescence‐ or radio‐labeling for imaging, controlled delivery of therapeutic agents and bioanalysis.
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Dates and versions

hal-02332497 , version 1 (24-10-2019)

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Michèle Salmain, Nathalie Fischer-Durand, Bogna Rudolf. Bioorthogonal Conjugation of Transition Organometallic Complexes to Peptides and Proteins: Strategies and Applications. European Journal of Inorganic Chemistry, 2020, 2020 (1), pp.21-35. ⟨10.1002/ejic.201900810⟩. ⟨hal-02332497⟩
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