Skip to Main content Skip to Navigation
Journal articles

Comparing interferon‐free with interferon‐based regimens in HCV patients: Rogers phenomenon and Simpson’s paradox

Abstract : Comparisons of time-to-event clinical outcomes between patients with or without a sustained virological response (SVR) after treatment of chronic hepatitis C infection have been repeatedly reported in emphasizing the potential clinical impact of treatment. Combining recently published data from different therapeutic eras with simple examples, we show that comparisons of incidence rates by SVR status between patients treated with interferon-based and interferon-free regimens are flawed through confounding by prognosis. The relevant analysis for evaluating and comparing the clinical impact of these regimens should be a comparison between randomized treatment groups, irrespective of the SVR status.
Complete list of metadatas

Cited literature [8 references]  Display  Hide  Download

https://hal.sorbonne-universite.fr/hal-02437336
Contributor : Gestionnaire Hal-Su <>
Submitted on : Monday, January 13, 2020 - 5:08:49 PM
Last modification on : Tuesday, May 26, 2020 - 3:00:07 AM
Document(s) archivé(s) le : Tuesday, April 14, 2020 - 5:18:57 PM

File

Carrat_JViralHepatitis_RogersS...
Files produced by the author(s)

Identifiers

Citation

Fabrice Carrat, Pierre Nahon, Hélène Fontaine, Stanislas Pol, Gilles Hejblum. Comparing interferon‐free with interferon‐based regimens in HCV patients: Rogers phenomenon and Simpson’s paradox. Journal of Viral Hepatitis, Wiley-Blackwell, In press, 27 (3), pp.329-332. ⟨10.1111/jvh.13225⟩. ⟨hal-02437336⟩

Share

Metrics

Record views

251

Files downloads

251