Therapeutic Targeting of the Colorectal Tumor Stroma - Sorbonne Université
Article Dans Une Revue Gastroenterology Année : 2020

Therapeutic Targeting of the Colorectal Tumor Stroma

Résumé

Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, all of which affect the tumor microenvironment. Elements of the tumor microenvironment serve as therapeutic targets and might be used as prognostic factors. For example, immune checkpoint inhibitors are used to treat tumors with microsatellite instability, and anti-angiogenic agents may be used in combination with other drugs to slow or inhibit tumor growth. We review the features of the colorectal tumor stroma that are associated with patient outcomes and discuss potential therapeutic agents that target these features.

Mots clés

Fichier principal
Vignette du fichier
Fridman_edit_v5 Novak HAL.pdf (337.69 Ko) Télécharger le fichier
Origine Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

hal-02456347 , version 1 (27-01-2020)

Identifiants

Citer

Wolf H Fridman, Ian Miller, Catherine Sautès-Fridman, Annette T Byrne. Therapeutic Targeting of the Colorectal Tumor Stroma. Gastroenterology, 2020, 158 (2), pp.303-321. ⟨10.1053/j.gastro.2019.09.045⟩. ⟨hal-02456347⟩
528 Consultations
1032 Téléchargements

Altmetric

Partager

More