Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates - Sorbonne Université
Journal Articles Nature Biomedical Engineering Year : 2020

Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates

Fabrice Arcizet
Pierre Daye
  • Function : Author
  • PersonId : 942186
Elric Esposito
Henri Lorach
  • Function : Author
Guillaume Chenegros
  • Function : Author
  • PersonId : 862953
Pierre Pouget
  • Function : Author
  • PersonId : 942190
Serge Picaud

Abstract

Retinal dystrophies and age-related macular degeneration related to photoreceptor degeneration can cause blindness. In blind patients, although the electrical activation of the residual retinal circuit can provide useful artificial visual perception, the resolutions of current retinal prostheses have been limited either by large electrodes or small numbers of pixels. Here we report the evaluation, in three awake non-human primates, of a previously reported near-infrared-light-sensitive photovoltaic subretinal prosthesis. We show that multipixel stimulation of the prosthesis within radiation safety limits enabled eye tracking in the animals, that they responded to stimulations directed at the implant with repeated saccades and that the implant-induced responses were present two years after device implantation. Our findings pave the way for the clinical evaluation of the prosthesis in patients affected by dry atrophic age-related macular degeneration.
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Dates and versions

hal-02505613 , version 1 (11-03-2020)

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Paul-Henri Prévot, Kevin Gehere, Fabrice Arcizet, Himanshu Akolkar, Mina A Khoei, et al.. Behavioural responses to a photovoltaic subretinal prosthesis implanted in non-human primates. Nature Biomedical Engineering, 2020, 4 (2), pp.172-180. ⟨10.1038/s41551-019-0484-2⟩. ⟨hal-02505613⟩
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