Treatment and unmet needs in steroid-refractory acute graft-versus-host disease - Sorbonne Université
Journal Articles Leukemia Year : 2020

Treatment and unmet needs in steroid-refractory acute graft-versus-host disease

Abstract

Acute graft-versus-host disease (aGVHD) is a common complication of allogeneic hematopoietic stem cell transplantation (alloHCT) and is a major cause of morbidity and mortality. Systemic steroid therapy is the first-line treatment for aGVHD, although about half of patients will become refractory to treatment. As the number of patients undergoing alloHCT increases, developing safe and effective treatments for aGVHD will become increasingly important, especially for those whose disease becomes refractory to systemic steroid therapy. This paper reviews current treatment options for patients with steroid-refractory aGVHD and discusses data from recently published clinical studies to outline emerging therapeutic strategies.
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Dates and versions

hal-02552361 , version 1 (23-04-2020)

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Florent Malard, Xiao-Jun Huang, Joycelyn P y Sim. Treatment and unmet needs in steroid-refractory acute graft-versus-host disease. Leukemia, 2020, ⟨10.1038/s41375-020-0804-2⟩. ⟨hal-02552361⟩
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