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The meta-memory ratio: a new cohort- independent way to measure cognitive awareness in asymptomatic individuals at risk for Alzheimer's disease

Abstract : Background: Lack of awareness of cognitive decline (ACD) has been described at the preclinical and prodromal stages of Alzheimer's disease (AD). In this study, we introduced a meta-memory ratio (MMR) and explored how it is associated with neuroimaging AD biomarkers in asymptomatic individuals at risk for AD. Method: Four hundred forty-eight cognitively healthy participants from two cohorts of subjective memory complainers (INSIGHT-PreAD and ADNI) were included. Regression models were used to assess the impact of AD biomarkers on the MMR. Result: In both cohorts, there was a significant quadratic effect of cerebral amyloidosis on the MMR value. In particular, participants had a high ACD up to the amyloid positivity threshold, above which a decrease of ACD was eventually observed as the amyloid load increased. Conclusion: This nonlinear evolution of ACD in very early AD must be taken into account in clinical care and for trial enrollment as well.
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Submitted on : Wednesday, May 20, 2020 - 1:30:02 PM
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Geoffroy Gagliardi, Marion Houot, Federica Cacciamani, Marie-Odile Habert, Bruno Dubois, et al.. The meta-memory ratio: a new cohort- independent way to measure cognitive awareness in asymptomatic individuals at risk for Alzheimer's disease. Alzheimer's Research and Therapy, BioMed Central, 2020, 12 (1), pp.57. ⟨10.1186/s13195-020-00626-1⟩. ⟨hal-02613801⟩

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