Age-specific changes in left ventricular diastolic function: A velocity-encoded magnetic resonance imaging study - Sorbonne Université
Journal Articles European Radiology Year : 2015

Age-specific changes in left ventricular diastolic function: A velocity-encoded magnetic resonance imaging study

Carine Defrance
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  • PersonId : 920072
Magalie Ladouceur
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  • PersonId : 981832

Abstract

Objectives: Our objectives were to assess the ability of phasecontrast MRI (PC-MRI) to detect sub-clinical age-related variations of left ventricular (LV) diastolic parameters and thus to provide age-related reference ranges currently available for echocardiography but not for MRI-PC, and to identify independent associates of such variations. Methods: We studied 100 healthy volunteers (age = 42 ± 15years, 50 females) who had MRI with simultaneous blood pressure measurements. LV mass and volumes were assessed. Semiautomated analysis of PC-MRI data provided: 1) early transmitral (Ef) and atrial (Af) peak filling flow-rates (ml/s) and filling volume (FV), 2) deceleration time (DT), isovolumic relaxation time (IVRT), and 3) early myocardial longitudinal (E') peak velocity. Results: MRI-PC diastolic parameters were reproducible as reflected by low coefficients of variations (ranged between 0.31 to 6.26 %). Peak myocardial velocity E' (r = -0.63, p < 0.0001) and flow-rate parameters were strongly and independently associated to age (Ef/Af:r = -0.63, DT:r = 0.46, IVRT:r = 0.44, Ef/FV:r = -0.55, Af/FV:r = 0.56, p < 0.0001). Furthermore, LV relaxation parameters (E', DT, IVRT), were independently associated to LV remodelling (LV mass/end-diastolic volume) and myocardial wall thickness (p < 0.01). Conclusions: PC-MRI age-related reference ranges of diastolic parameters are provided. Such parameters might be useful for a fast, reproducible and reliable characterization of diastolic function in patients referred for clinical MRI exam
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hal-02635380 , version 1 (30-08-2022)

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Golmehr Ashrafpoor, Emilie Bollache, Alban Redheuil, Alain de Cesare, Alain Giron, et al.. Age-specific changes in left ventricular diastolic function: A velocity-encoded magnetic resonance imaging study. European Radiology, 2015, 25 (4), pp.1077-1086. ⟨10.1007/s00330-014-3488-z⟩. ⟨hal-02635380⟩
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