Isoxazole‐Derived Aroylhydrazones and Their Dinuclear Copper(II) Complexes Show Antiproliferative Activity on Breast Cancer Cells with a Potentially Alternative Mechanism Of Action - Sorbonne Université Access content directly
Journal Articles ChemBioChem Year : 2020

Isoxazole‐Derived Aroylhydrazones and Their Dinuclear Copper(II) Complexes Show Antiproliferative Activity on Breast Cancer Cells with a Potentially Alternative Mechanism Of Action

Abstract

Cytotoxicity contrast : Two aroylhydrazonic ligands and their acetate/perchlorate dicopper complexes were synthesized and characterized by various spectroscopic and analytical techniques, including X‐ray diffraction. They were shown to interact with DNA and display contrasted cytotoxicity on breast cancer cells. Their biological properties were linked to their ability to undergo chelation/transmetallation with biologically relevant metal ions.
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hal-02749888 , version 1 (07-12-2020)

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Jesica Paola Rada, Jérémy Forté, Geoffrey Gontard, Vincent Corce, Michèle Salmain, et al.. Isoxazole‐Derived Aroylhydrazones and Their Dinuclear Copper(II) Complexes Show Antiproliferative Activity on Breast Cancer Cells with a Potentially Alternative Mechanism Of Action. ChemBioChem, 2020, 21 (17), pp.2474-2486. ⟨10.1002/cbic.202000122⟩. ⟨hal-02749888⟩
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