Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making - Sorbonne Université
Journal Articles eLife Year : 2020

Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making

Abstract

Involvement of dopamine in regulating exploration during decision-making has long been hypothesized, but direct causal evidence in humans is still lacking. Here, we use a combination of computational modeling, pharmacological intervention and functional magnetic resonance imaging to address this issue. Thirty-one healthy male participants performed a restless four-armed bandit task in a within-subjects design under three drug conditions: 150 mg of the dopamine precursor L-dopa, 2 mg of the D2 receptor antagonist haloperidol, and placebo. Choices were best explained by an extension of an established Bayesian learning model accounting for perseveration, directed exploration and random exploration. Modeling revealed attenuated directed exploration under L-dopa, while neural signatures of exploration, exploitation and prediction error were unaffected. Instead, L-dopa attenuated neural representations of overall uncertainty in insula and dorsal anterior cingulate cortex. Our results highlight the computational role of these regions in exploration and suggest that dopamine modulates how this circuit tracks accumulating uncertainty during decision-making.
Fichier principal
Vignette du fichier
elife-51260-v1.pdf (4.41 Mo) Télécharger le fichier
Origin Publication funded by an institution
Loading...

Dates and versions

hal-02877277 , version 1 (22-06-2020)

Identifiers

Cite

Karima Chakroun, David Mathar, Antonius Wiehler, Florian Ganzer, Jan Peters. Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making. eLife, 2020, 9, pp.e51260. ⟨10.7554/eLife.51260⟩. ⟨hal-02877277⟩
157 View
86 Download

Altmetric

Share

More