Skip to Main content Skip to Navigation
Journal articles

Potential Causes and Consequences of Gastrointestinal Disorders during a SARS-CoV-2 Infection

Abstract : Coronaviruses cause several human diseases, including severe acute respiratory syndrome. The global coronavirus disease 2019 (COVID-19) pandemic has become a huge threat to humans. Intensive research on the pathogenic mechanisms used by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is urgently needed-notably to identify potential drug targets. Clinical studies of patients with COVID-19 have shown that gastrointestinal disorders appear to precede or follow the respiratory symptoms. Here, we review gastrointestinal disorders in patients with COVID-19, suggest hypothetical mechanisms leading to gut symptoms, and discuss the potential consequences of gastrointestinal disorders on the outcome of the disease. Lastly, we discuss the role of the gut microbiota during respiratory viral infections and suggest that targeting gut dysbiosis may help to control the pathogenesis of COVID-19.
Document type :
Journal articles
Complete list of metadatas

Cited literature [74 references]  Display  Hide  Download

https://hal.sorbonne-universite.fr/hal-02934850
Contributor : Gestionnaire Hal-Su <>
Submitted on : Wednesday, September 9, 2020 - 4:49:49 PM
Last modification on : Tuesday, November 3, 2020 - 3:30:06 PM

File

1-s2.0-S2211124720308962-main....
Publication funded by an institution

Identifiers

Citation

François Trottein, Harry Sokol. Potential Causes and Consequences of Gastrointestinal Disorders during a SARS-CoV-2 Infection. Cell Reports, Elsevier Inc, 2020, 32 (3), pp.107915. ⟨10.1016/j.celrep.2020.107915⟩. ⟨hal-02934850⟩

Share

Metrics

Record views

34

Files downloads

59