Head-to-head comparison of the diagnostic performances of Rubidium-PET and SPECT with CZT camera for the detection of myocardial ischemia in a population of women and overweight individuals - Sorbonne Université
Journal Articles Journal of Nuclear Cardiology Year : 2020

Head-to-head comparison of the diagnostic performances of Rubidium-PET and SPECT with CZT camera for the detection of myocardial ischemia in a population of women and overweight individuals

Renata Chequer
  • Function : Author
Toni Alfaiate
  • Function : Author
Hamza Regaieg
  • Function : Author
Jérémie Abtan
  • Function : Author
Louis Potier
  • Function : Author
Cédric Laouénan
Ronan Roussel
  • Function : Author

Abstract

Background: The aim of this study was to compare the diagnostic performances for the detection of myocardial ischemia of 82-Rb-PET-MPS and 99m-Tc-SPECT-MPS in overweight individuals and women. Methods and results: Men with BMI ≥ 25 and women referred for MPS were considered for inclusion. All individuals underwent 99m-Tc-SPECT-MPS with CZT cameras and 82-Rb-PET-MPS in 3D-mode. Individuals with at least one positive MPS were referred for coronary angiography (CA) with FFR measurements. A criterion for positivity was a composite endpoint including significant stenosis on CA or, in the absence of CA, the occurrence of acute coronary event during the following year. 313 patients (46% women) with mean BMI of 31.8 ± 6.5 were included. Sensitivity for the detection of myocardial ischemia was higher with 82-Rb-PET-MPS compared with 99m-Tc-SPECT-MPS (85% vs. 57%, P < .05); specificity was equally high with both imaging techniques (93% vs. 94%, P > .05). 82-Rb-PET allowed for a more accurate detection of patients with a high-risk coronary artery disease (HR-CAD) than 99m-Tc-SPECT-MPS (AUC = 0.86 vs. 0.75, respectively; P = .04). Conclusions: In women and overweight individuals, 82-Rb-PET-MPS provides higher sensitivity for the detection of myocardial ischemia than 99m-Tc-SPECT-MPS thanks to a better image quality and an improved detection of HR-CAD.
No file

Dates and versions

hal-02964652 , version 1 (12-10-2020)

Identifiers

Cite

Fabien Hyafil, Renata Chequer, Emmanuel Sorbets, Candice Estellat, Gregory Ducrocq, et al.. Head-to-head comparison of the diagnostic performances of Rubidium-PET and SPECT with CZT camera for the detection of myocardial ischemia in a population of women and overweight individuals. Journal of Nuclear Cardiology, 2020, 27 (3), pp.755-768. ⟨10.1007/s12350-018-01557-z⟩. ⟨hal-02964652⟩
53 View
0 Download

Altmetric

Share

More