Rational Optimization of Lewis‐Acid Catalysts for Direct Alcohol Amination, Part 2 – Titanium Triflimide as New Active Catalyst
Résumé
The reactivity of a new titanium triflimide salt (see Part 1) was investigated for the direct amination of alcohols. The combination of this new Lewis acid with pyridine‐based ligands allowed a significant increase of activity. The scope of the reaction was increased compared to other Lewis‐acid‐based protocols. Finally, mechanistic insights based on EPR spectroscopy and DFT calculations are provided.
Domaines
Chimie
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Payard et al. - 2020 - Rational Optimization of Lewis-Acid Catalysts for .pdf (472.41 Ko)
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