ARID2 Chromatin Remodeler in Hepatocellular Carcinoma - Sorbonne Université
Journal Articles Cells Year : 2020

ARID2 Chromatin Remodeler in Hepatocellular Carcinoma

Abstract

Chromatin remodelers are found highly mutated in cancer including hepatocellular carcinoma. These mutations frequently occur in ARID (AT-rich Interactive Domain) genes, encoding subunits of the ATP-dependent SWI/SNF remodelers. The increasingly prevalent complexity that surrounds the functions and specificities of the highly modular BAF (BG1/BRM-associated factors) and PBAF (polybromo-associated BAF) complexes, including ARID1A/B or ARID2, is baffling. The involvement of the SWI/SNF complexes in diverse tissues and processes, and especially in the regulation of gene expression, multiplies the specific outcomes of specific gene alterations. A better understanding of the molecular consequences of specific mutations impairing chromatin remodelers is needed. In this review, we summarize what we know about the tumor-modulating properties of ARID2 in hepatocellular carcinoma.
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hal-03007683 , version 1 (16-11-2020)

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Robin Loesch, Linda Chenane, Sabine Colnot. ARID2 Chromatin Remodeler in Hepatocellular Carcinoma. Cells, 2020, 9 (10), pp.2152. ⟨10.3390/cells9102152⟩. ⟨hal-03007683⟩
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