Adaptive-glasses time-domain FFOCT for wide-field high-resolution retinal imaging with increased SNR - Sorbonne Université
Journal Articles Optics Letters Year : 2020

Adaptive-glasses time-domain FFOCT for wide-field high-resolution retinal imaging with increased SNR

Kate Grieve
  • Function : Author
  • PersonId : 937920
Pedro Mecê

Abstract

The highest three-dimensional (3D) resolution possible in in vivo retinal imaging is achieved by combining optical coherence tomography (OCT) and adaptive optics. However, this combination brings important limitations, such as small field-of-view and complex, cumbersome systems, preventing so far the translation of this technology from the research lab to clinics. In this Letter, we mitigate these limitations by combining our compact time-domain full-field OCT (FFOCT) with a multi-actuator adaptive lens positioned just in front of the eye, in a technique we call the adaptive-glasses wavefront sensorless approach. Through this approach, we demonstrate that ocular aberrations can be corrected, increasing the FFOCT signal-to-noise ratio (SNR) and enabling imaging of different retinal layers with a 3D cellular resolution over a 5∘×5∘ field-of-view, without apparent anisoplanatism.
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Dates and versions

hal-03020742 , version 1 (24-11-2020)

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Cite

Jules Scholler, Kassandra Groux, Kate Grieve, Claude Boccara, Pedro Mecê. Adaptive-glasses time-domain FFOCT for wide-field high-resolution retinal imaging with increased SNR. Optics Letters, 2020, ⟨10.1364/OL.403135⟩. ⟨hal-03020742⟩
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