Derivation, Validation, and Prognostic Utility of a Prediction Rule for Nonresponse to Clopidogrel

Dominick Angiolillo; Davide Capodanno; Nicolas Danchin; Tabassome Simon; Thomas Bergmeijer; Jurrien ten Berg; Dirk Sibbing; Matthew Price

doi:10.1016/j.jcin.2020.01.226

Journal Articles JACC: Cardiovascular Interventions Year : 2020

Derivation, Validation, and Prognostic Utility of a Prediction Rule for Nonresponse to Clopidogrel

Derivation, Validation, and Prognostic Utility of a Prediction Rule for Nonresponse to Clopidogrel: The ABCD-GENE Score.

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Dominick Angiolillo

Function : Author

Davide Capodanno

Function : Author

Nicolas Danchin

Function : Author

Tabassome Simon

Function : Author
PersonId : 741176
IdHAL : tabassome-simon
ORCID : 0000-0002-4550-0450
IdRef : 070443122

Centre de Ressources Biologiques APHP-SU

Thomas Bergmeijer

Function : Author

Jurrien ten Berg

Function : Author

Dirk Sibbing

Function : Author
PersonId : 786699
ORCID : 0000-0002-0698-2696

Matthew Price

Function : Author

Abstract

The aim of this study was to develop a risk score integrating cytochrome P450 2C19 loss-of-function genotypes with clinical risk factors influencing clopidogrel response that would allow the identification with more precision of subjects at risk for high platelet reactivity (HPR) and adverse clinical outcomes.

Keywords

clopidogrel genetic testing outcomes risk factors

Domains

Life Sciences [q-bio]

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https://hal.sorbonne-universite.fr/hal-03030882

Submitted on : Monday, November 30, 2020-11:52:48 AM

Last modification on : Thursday, April 18, 2024-1:32:02 PM

Dates and versions

hal-03030882 , version 1 (30-11-2020)

Identifiers

HAL Id : hal-03030882 , version 1
DOI : 10.1016/j.jcin.2020.01.226
PUBMED : 32139218

Cite

Dominick Angiolillo, Davide Capodanno, Nicolas Danchin, Tabassome Simon, Thomas Bergmeijer, et al.. Derivation, Validation, and Prognostic Utility of a Prediction Rule for Nonresponse to Clopidogrel. JACC: Cardiovascular Interventions, 2020, 13 (5), pp.606-617. ⟨10.1016/j.jcin.2020.01.226⟩. ⟨hal-03030882⟩

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