Different real‐time degradation scenarios of functionalized poly(ε‐caprolactone) for biomedical applications - Sorbonne Université Access content directly
Journal Articles Journal of Applied Polymer Science Year : 2021

Different real‐time degradation scenarios of functionalized poly(ε‐caprolactone) for biomedical applications

Abstract

Anterior cruciate ligament (ACL) ruptures are a much‐commented injury as it can end the season or even career of professional athletes. However, the recovery of a patient from the general population is no less painful during the long period required by current treatments. Artificial ligaments could improve this healing, yet, orthopedic surgeons are still cautious about permanent ACL implants. Therefore, combining biodegradation and bioactivity could be a key feature for the popularization of these devices. This study aim at evaluating the real‐time degradation of poly(ε‐caprolactone) (PCL) grafted with the bioactive polymer sodium polystyrene sulfonate in different scenarios. PCL physical–chemical properties were evaluated before and after degradation. In addition, in vitro experiments were realized to confirm the long term influence of the grafting on cell response. Altogether, we were able to show different degradations scenarios, enabling to study the impact of degradation environment on degradation mode and rate of functionalized PCL.
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Origin : Publication funded by an institution

Dates and versions

hal-03119964 , version 1 (25-01-2021)

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André Rangel, Tuan Ngoc Nguyen, Christophe Egles, Veronique Migonney. Different real‐time degradation scenarios of functionalized poly(ε‐caprolactone) for biomedical applications. Journal of Applied Polymer Science, 2021, pp.50479. ⟨10.1002/app.50479⟩. ⟨hal-03119964⟩
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