Modifications to the classical rat aortic ring model to allow vascular degeneration studies - Sorbonne Université
Article Dans Une Revue STAR Protocols Année : 2021

Modifications to the classical rat aortic ring model to allow vascular degeneration studies

Résumé

The classical aortic ring model is well suited for deciphering pro-angiogenic processes. Here, we propose simple modifications of the standard protocol to study various anti-angiogenic processes from growth arrest to capillary degeneration. Aortic rings are cultured under basal conditions for 6 days to allow physiological vessel sprouting and then split into treatment groups to follow capillary growth or degeneration for an additional 2 days.
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Dates et versions

hal-03131466 , version 1 (04-02-2021)

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Guillaume Blot, Thérèse-Marie Sartoris, Florian Sennlaub, Xavier Guillonneau. Modifications to the classical rat aortic ring model to allow vascular degeneration studies. STAR Protocols, 2021, 2 (1), pp.100281. ⟨10.1016/j.xpro.2020.100281⟩. ⟨hal-03131466⟩
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