Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis - Sorbonne Université
Journal Articles Frontiers in Molecular Neuroscience Year : 2021

Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis

Abstract

Alzheimer’s disease (AD) is the most common form of dementia. Its prevalence will significantlyincrease in the coming decades, whereas no efficient treatment is currently available. AD hastwo main neuropathological lesions: amyloid plaques and neurofibrillary tangles (NFTs). Amyloidplaques are composed of amyloid ß (Aß) peptides cleaved from the Amyloid Precursor Protein(APP) (Glenner and Wong, 1984). NFTs, present in the brain of AD and related neurodegenerativediseases, are constituted of tau proteins (Brion et al., 1985) in hyperphosphorylated and aggregatedform (Wang and Mandelkow, 2016).
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Dates and versions

hal-03136084 , version 1 (09-02-2021)

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Kunie Ando, Sarah Houben, Mégane Homa, Marie-Ange de Fisenne, Marie-Claude Potier, et al.. Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis. Frontiers in Molecular Neuroscience, 2021, 13, ⟨10.3389/fnmol.2020.583755⟩. ⟨hal-03136084⟩
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