Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis

Alzheimer’s disease (AD) is the most common form of dementia. Its prevalence will significantlyincrease in the coming decades, whereas no efficient treatment is currently available. AD hastwo main neuropathological lesions: amyloid plaques and neurofibrillary tangles (NFTs). Amyloidplaques are composed of amyloid ß (Aß) peptides cleaved from the Amyloid Precursor Protein(APP) (Glenner and Wong, 1984). NFTs, present in the brain of AD and related neurodegenerativediseases, are constituted of tau proteins (Brion et al., 1985) in hyperphosphorylated and aggregatedform (Wang and Mandelkow, 2016).

Keywords

Alzheimer's disease endocytosis genome-wide association study phosphoinositides tau amyloid ß

Domains

Neurons and Cognition [q-bio.NC]

Fichier principal

fnmol-13-583755.pdf (635.96 Ko)

Origin	Publication funded by an institution

Gestionnaire HAL 5 Sorbonne Université : Connect in order to contact the contributor

https://hal.sorbonne-universite.fr/hal-03136084

Submitted on : Tuesday, February 9, 2021-2:37:02 PM

Last modification on : Monday, July 15, 2024-3:10:33 PM

Long-term archiving on : Monday, May 10, 2021-6:48:32 PM

Dates and versions

hal-03136084 , version 1 (09-02-2021)

Identifiers

HAL Id : hal-03136084 , version 1
DOI : 10.3389/fnmol.2020.583755

Cite

Kunie Ando, Sarah Houben, Mégane Homa, Marie-Ange de Fisenne, Marie-Claude Potier, et al.. Alzheimer's Disease: Tau Pathology and Dysfunction of Endocytosis. Frontiers in Molecular Neuroscience, 2021, 13, ⟨10.3389/fnmol.2020.583755⟩. ⟨hal-03136084⟩

Export

BibTeX XML-TEI Dublin Core DC Terms EndNote DataCite

Collections

INSERM CNRS ICM SORBONNE-UNIVERSITE SU-MEDECINE

75 View

44 Download