Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly † - Sorbonne Université
Article Dans Une Revue Polymer Chemistry Année : 2020

Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly †

Résumé

Core–shell nanoparticles (NPs) with a boron-rich core were synthesized by RAFT-mediated polymerization-induced self-assembly using a new methacrylic boronate ester monomer. Under specific conditions, sub-100 nm spherical NPs could be obtained at high conversions by either emulsion or dispersion RAFT polymerization using poly(oligo(ethylene glycol) methacrylate) (POEGMA) dithiobenozate-based chain transfer agents. Phenylboronic acid surface-functionalized NPs were obtained using a telechelic POEGMA. Primary data on biocompatibility is provided and suggests suitability as boron delivery agent for boron neutron capture therapy.

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Chimie
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Dates et versions

hal-03145906 , version 1 (18-02-2021)

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Lin-Chiang Sherlock Huang, Dao Le, I-Lun Hsiao, Susanne Fritsch-Decker, Christian Hald, et al.. Boron-rich, cytocompatible block copolymer nanoparticles by polymerization-induced self-assembly †. Polymer Chemistry, 2020, 12 (1), pp.50-56. ⟨10.1039/d0py00710b⟩. ⟨hal-03145906⟩
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