Multisystem inflammatory syndrome in children rose and fell with the first wave of the COVID-19 pandemic in France - Sorbonne Université Accéder directement au contenu
Article Dans Une Revue Acta Paediatrica Année : 2021

Multisystem inflammatory syndrome in children rose and fell with the first wave of the COVID-19 pandemic in France

Résumé

Aim: This study determined the influence of the COVID-19 pandemic on the occurrence of multisystem inflammatory syndrome in children (MIS-C) and compared the main characteristics of MIS-C and Kawasaki disease (KD). Methods: We included patients aged up to 18 years of age who were diagnosed with MIS-C or KD in a paediatric university hospital in Paris from 1 January 2018 to 15 July 2020. Clinical, laboratory and imaging characteristics were compared, and new French COVID-19 cases were correlated with MIS-C cases in our hospital. Results: There were seven children with MIS-C, from 6 months to 12 years of age, who were all positive for the virus that causes COVID-19, and 40 virus-negative children with KD. Their respective characteristics were as follows: under 5 years of age (14.3% vs. 85.0%), paediatric intensive care unit admission (100% vs. 10.0%), abdominal pain (71.4% vs. 12.5%), myocardial dysfunction (85.7% vs. 5.0%), shock syndrome (85.7% vs. 2.5%) and mean and standard deviation C-reactive protein (339 ± 131 vs. 153 ± 87). There was a strong lagged correlation between the rise and fall in MIS-C patients and COVID-19 cases. Conclusion: The rise and fall of COVID-19 first wave mirrored the MIS-C cases. There were important differences between MIS-C and KD.
Fichier principal
Vignette du fichier
Carbajal R Rise and fall of a French outbreak of SARS-CoV-2 related MISC ACTA.pdf (1.5 Mo) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)

Dates et versions

hal-03152589 , version 1 (25-02-2021)

Identifiants

Citer

Ricardo Carbajal, Mathie Lorrot, Yael Levy, Emmanuel Grimprel, Thibault Lecarpentier, et al.. Multisystem inflammatory syndrome in children rose and fell with the first wave of the COVID-19 pandemic in France. Acta Paediatrica, 2021, 110 (3), pp.922-932. ⟨10.1111/apa.15667⟩. ⟨hal-03152589⟩
71 Consultations
45 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More