Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation: Mass seroepidemiological screening in Castiglione d’Adda, Italy - Sorbonne Université
Journal Articles PLoS ONE Year : 2021

Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation: Mass seroepidemiological screening in Castiglione d’Adda, Italy

Rossana Rondanin
  • Function : Author
Andrea Prina
  • Function : Author
Bruno Alessandro Rivieccio
  • Function : Author
Giacomo Buonanno
  • Function : Author
Cosimo Ottomano
  • Function : Author

Abstract

Castiglione D'Adda is one of the municipalities more precociously and severely affected by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) epidemic in Lombardy. With our study we aimed to understand the diffusion of the infection by mass serological screening. We searched for SARS-CoV-2 IgGs in the entire population on a voluntary basis using lateral flow immunochromatographic tests (RICT) on capillary blood (rapid tests). We then performed chemioluminescent serological assays (CLIA) and naso-pharyngeal swabs (NPS) in a randomized representative sample and in each subject with a positive rapid test. Factors associated with RICT IgG positivity were assessed by uni- and multivariate logistic regression models. Out of the 4143 participants, 918 (22·2%) showed RICT IgG positivity. In multivariable analysis, IgG positivity increases with age, with a significant non-linear effect (p = 0·0404). We found 22 positive NPSs out of the 1330 performed. Albeit relevant, the IgG prevalence is lower than expected and suggests that a large part of the population remains susceptible to the infection. The observed differences in prevalence might reflect a different infection susceptibility by age group. A limited persistence of active infections could be found after several weeks after the epidemic peak in the area.
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Dates and versions

hal-03179206 , version 1 (24-03-2021)

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Gabriele Pagani, Andrea Giacomelli, Federico Conti, Dario Bernacchia, Rossana Rondanin, et al.. Prevalence of SARS-CoV-2 in an area of unrestricted viral circulation: Mass seroepidemiological screening in Castiglione d’Adda, Italy. PLoS ONE, 2021, 16 (2), pp.e0246513. ⟨10.1371/journal.pone.0246513⟩. ⟨hal-03179206⟩
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