Whole blood mRNA levels of S1PR4 associated with cerebral vasospasm after subarachnoid hemorrhage - Sorbonne Université
Journal Articles Journal of Neurosurgery Year : 2020

Whole blood mRNA levels of S1PR4 associated with cerebral vasospasm after subarachnoid hemorrhage

Frédéric Clarençon
Eimad Shotar
  • Function : Author
  • PersonId : 1083686

Abstract

OBJECTIVE: The authors sought to identify mRNA biomarkers of cerebral vasospasm in whole blood of patients suffering from aneurysmal subarachnoid hemorrhage (aSAH). METHODS: A prospective transcriptomic study for vasospasm was conducted in whole blood samples of 44 aSAH patients who developed (VSP+ group, n = 22) or did not develop (VSP− group, n = 22) vasospasm. Samples from all patients were profiled for 21,460 mRNA probes using the Illumina Human HT12v4.0 array. Differential statistical analysis was performed using a linear mixed model. RESULTS: Levels of sphingosine-1-phosphate receptor 4 (S1PR4) mRNA were significantly higher (p = 8.03 × 10−6) at presentation in patients who developed vasospasm after aSAH than in patients who did not. CONCLUSIONS: The results, which are consistent with findings of previous experimental investigations conducted in animal models, support the role of S1PR4 and its ligand, sphingosine-1-phosphate (S1P), in arterial-associated vasoconstriction, which suggests that S1PR4 could be used as a biomarker for cerebral vasospasm in aSAH patients.
Fichier principal
Vignette du fichier
Pulcrano-Nicolas et al. - 2019 - Whole blood levels of S1PR4 mRNA associated with c.pdf (343.47 Ko) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-03181305 , version 1 (25-03-2021)

Identifiers

Cite

Anne-Sophie Pulcrano-Nicolas, Alice Jacquens, Carole Proust, Frédéric Clarençon, Claire Perret, et al.. Whole blood mRNA levels of S1PR4 associated with cerebral vasospasm after subarachnoid hemorrhage. Journal of Neurosurgery, 2020, 133 (6), pp.1837-1841. ⟨10.3171/2019.9.JNS191305⟩. ⟨hal-03181305⟩
76 View
233 Download

Altmetric

Share

More