LDL Cholesterol: ‘The Times They Are A-Changin’ - Sorbonne Université
Article Dans Une Revue Clinical Chemistry Année : 2020

LDL Cholesterol: ‘The Times They Are A-Changin’

Résumé

More than ever, the circulating concentration of low-density lipoprotein–cholesterol (LDL-C) has become a key criterion for the assessment of cardiovascular risk worldwide, and in turn, for clinical management of such risk. This “fait accompli” in large part reflects the recognition of the causality of LDL particles in the pathophysiology of atherosclerotic cardiovascular disease (ASCVD), and of the robust body of evidence demonstrating that efficacious and sustained lowering of LDL-C concentrations over time confers marked reduction in both risk and cardiovascular events (1,). As a consequence, many national and international guidelines for ASCVD prevention now focus on LDL-C targets as a function of the level of global risk in secondary prevention...
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Dates et versions

hal-03187050 , version 1 (31-03-2021)

Identifiants

Citer

M John Chapman, Philippe Giral, Patrice Therond. LDL Cholesterol: ‘The Times They Are A-Changin’. Clinical Chemistry, 2020, 66 (9), pp.1136-1139. ⟨10.1093/clinchem/hvaa110⟩. ⟨hal-03187050⟩
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