Editorial: Brain-Targeted Autoimmunity: Beyond Multiple Sclerosis - Sorbonne Université
Journal Articles Frontiers in Immunology Year : 2021

Editorial: Brain-Targeted Autoimmunity: Beyond Multiple Sclerosis

Abstract

There is mounting evidence indicating that brain-targeted autoimmunity develops in a large range of neurological conditions in which the involvement of the adaptive immune system was not previously envisioned. Beyond multiple sclerosis and a few central nervous system (CNS) disorders acknowledged to be autoimmune by nature, it now appears that multiple neurological conditions are accompanied by brain-targeted autoimmune processes. The eleven articles gathered in this Research Topic fall into four main research themes, which represent the likely focus of major investigative efforts in the near future: i) links between physiological and pathological brain-targeted autoimmunity, ii) the functional impact of post-lesional brain-targeted autoimmunity, iii) the role of brain-targeted autoimmunity in neurodevelopmental and neurodegenerative disorders, iv) the emergence of new clinical entities associated with brain-targeted autoimmunity. In this editorial, we first provide a brief summary of the main advances presented by these articles. We then discuss the concept of “brain-targeted autoimmunity” and how to refine it in order to improve our pathophysiological understanding of a growing array of CNS diseases.
Fichier principal
Vignette du fichier
fimmu-12-677577.pdf (203.43 Ko) Télécharger le fichier
Origin Publication funded by an institution

Dates and versions

hal-03190313 , version 1 (06-04-2021)

Identifiers

Cite

Serge Nataf, Stéphane Hunot, Guillaume Dorothée, Roland Liblau. Editorial: Brain-Targeted Autoimmunity: Beyond Multiple Sclerosis. Frontiers in Immunology, 2021, 12, ⟨10.3389/fimmu.2021.677577⟩. ⟨hal-03190313⟩
77 View
30 Download

Altmetric

Share

More