Presence of the neonatal Staphylococcus capitis outbreak clone (NRCS-A) in prosthetic joint infections - Sorbonne Université
Journal Articles Scientific Reports Year : 2020

Presence of the neonatal Staphylococcus capitis outbreak clone (NRCS-A) in prosthetic joint infections

Abstract

Staphylococcus capitis is a coagulase-negative staphylococcus that has been described primarily as causing bloodstream infections in neonatal intensive care units (NICUs), but has also recently been described in prosthetic joint infections (PJIs). The multidrug-resistant S. capitis subsp. urealyticus clone NRCS-A, comprising three sublineages, is prevalent in NICUs across the world, but its impact on other patient groups such as those suffering from PJIs or among adults planned for arthroplasty is unknown. Genome sequencing and subsequent analysis were performed on a Swedish collection of PJI isolates (n = 21), nasal commensals from patients planned to undergo arthroplasty (n = 20), NICU blood isolates (n = 9), operating theatre air isolates (n = 4), and reference strains (n = 2), in conjunction with an international strain collection (n = 248). The NRCS-A Outbreak sublineage containing the composite type V SCCmec-SCCcad/ars/cop element was present in PJIs across three Swedish hospitals. However, it was not found among nasal carrier strains, where the less virulent S. capitis subsp. capitis was most prevalent. The presence of the NRCS-A Outbreak clone in adult patients with PJIs demonstrates that dissemination occurs beyond NICUs. As this clone has several properties which facilitate invasive infections in patients with medical implants or immunosuppression, such as biofilm forming ability and multidrug resistance including heterogeneous glycopeptide-intermediate susceptibility, further research is needed to understand the reservoirs and distribution of this hospital-associated pathogen.
Fichier principal
Vignette du fichier
s41598-020-79225-x.pdf (2 Mo) Télécharger le fichier
Origin Publication funded by an institution

Dates and versions

hal-03213331 , version 1 (30-04-2021)

Identifiers

Cite

Staffan Tevell, Sharmin Baig, Bengt Hellmark, Patricia Martins Simoes, Thierry Wirth, et al.. Presence of the neonatal Staphylococcus capitis outbreak clone (NRCS-A) in prosthetic joint infections. Scientific Reports, 2020, 10 (1), pp.22389. ⟨10.1038/s41598-020-79225-x⟩. ⟨hal-03213331⟩
65 View
53 Download

Altmetric

Share

More