Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity - Sorbonne Université
Journal Articles PLoS ONE Year : 2021

Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity

Xiaoyi Chen
  • Function : Author
  • PersonId : 752823
  • IdHAL : xiaoyi-chen
Jules Russick
Maxime Meylan
Elie Mousseaux

Abstract

To investigate the mechanisms underlying the SARS-CoV-2 infection severity observed in patients with obesity, we performed a prospective study of 51 patients evaluating the impact of multiple immune parameters during 2 weeks after admission, on vital organs' functions according to body mass index (BMI) categories. High-dimensional flow cytometric characterization of immune cell subsets was performed at admission, 30 systemic cytokines/chemokines levels were sequentially measured, thirteen endothelial markers were determined at admission and at the zenith of the cytokines. Computed tomography scans on admission were quantified for lung damage and hepatic steatosis (n = 23). Abnormal BMI (> 25) observed in 72.6% of patients, was associated with a higher rate of intensive care unit hospitalization (p = 0.044). SARS-CoV-2 RNAaemia, peripheral immune cell subsets and cytokines/chemokines were similar among BMI groups. A significant association between inflammatory cytokines and liver, renal, and endothelial dysfunctions was observed only in patients with obesity (BMI > 30). In contrast, early signs of lung damage (ground-glass opacity) correlated with Th1/M1/inflammatory cytokines only in normal weight patients. Later lesions of pulmonary consolidation correlated with BMI but were independent of cytokine levels. Our study reveals distinct physiopathological mechanisms associated with SARS-CoV-2 infection in patients with obesity that may have important clinical implications.
Fichier principal
Vignette du fichier
journal.pone.0252026.pdf (2.52 Mo) Télécharger le fichier
Origin Publication funded by an institution

Dates and versions

hal-03239731 , version 1 (27-05-2021)

Identifiers

Cite

Marie-Agnès Dragon-Durey, Xiaoyi Chen, Amos Kirilovsky, Nadine Ben Hamouda, Carine El Sissy, et al.. Differential association between inflammatory cytokines and multiorgan dysfunction in COVID-19 patients with obesity. PLoS ONE, 2021, 16 (5), pp.e0252026. ⟨10.1371/journal.pone.0252026⟩. ⟨hal-03239731⟩
61 View
47 Download

Altmetric

Share

More