This paper quantifies and reduces the differences in emissions from the 2008 inventory with respect to the real ones through the use of satellite observations and modeling. Carbon monoxide column comparisons from the Infrared Atmospheric Sounding Interferometer (IASI) satellite data were made against columns obtained from the WRF-Chem model, during February 2011. The analysis was carried out at the satellite passage local time (approximately 10:00 LT) over Mexico City. The 2008 National Emissions Inventory generated by the Mexican Ministry of Environment and Natural Resources was utilized. An inversion method was applied to the modeled and observed column data. With the above, scaling factors were obtained for five regions and the concentration from the model domain boundaries, which were used to update the emissions. These were used in modeling and the result was compared with surface measurements. For Mexico City and the Metropolitan Area, a scaling factor equal to 0.43 was obtained when using the 2008 emissions inventory; for Toluca, Morelos and Puebla, a less than one factor was estimated, while for Hidalgo and the concentration from model boundaries it was close to two. The model performance was improved by an increment in the agreement index and a reduction on the mean square error when the updated CO emissions were used.