Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum - Sorbonne Université
Journal Articles Cell Reports Year : 2021

Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum

Abstract

Brain neurons arise from relatively few progenitors generating an enormous diversity of neuronal types. Nonetheless, a cardinal feature of mammalian brain neurogenesis is thought to be that excitatory and inhibitory neurons derive from separate, spatially segregated progenitors. Whether bi-potential progenitors with an intrinsic capacity to generate both lineages exist and how such a fate decision may be regulated are unknown. Using cerebellar development as a model, we discover that individual progenitors can give rise to both inhibitory and excitatory lineages. Gradations of Notch activity determine the fates of the progenitors and their daughters. Daughters with the highest levels of Notch activity retain the progenitor fate, while intermediate levels of Notch activity generate inhibitory neurons, and daughters with very low levels of Notch signaling adopt the excitatory fate. Therefore, Notch-mediated binary cell fate choice is a mechanism for regulating the ratio of excitatory to inhibitory neurons from common progenitors.
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Dates and versions

hal-03256874 , version 1 (10-06-2021)

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Tingting Zhang, Tengyuan Liu, Natalia Mora, Justine Guegan, Mathilde Bertrand, et al.. Generation of excitatory and inhibitory neurons from common progenitors via Notch signaling in the cerebellum. Cell Reports, 2021, 35 (10), pp.109208. ⟨10.1016/j.celrep.2021.109208⟩. ⟨hal-03256874⟩
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