Purpose: Vagus nerve stimulation (VNS) implantation is increasingly proposed in outpatient procedure. Some epilepsy syndromes are associated with severe neurodevelopmental disabilities (intellectual disability, autism) and often motor or sensory handicaps, making ambulatory surgery more complex. Methods: We prospectively assessed the feasibility and safety of outpatient VNS implantation in 26 adult drug-resistant epilepsy patients with severe intellectual disability between December 2017 and October 2020. Results: The male-to-female ratio was 0.9 and the mean age on surgery day was 23.1 years. Seventeen patients (65.4%) suffered from epileptic encephalopathy, 7 (26.9%) from cryptogenic or genetic generalized epilepsy and 2 (7.7%) from severe multifocal epilepsy. Postoperatively, all patients discharged the day of surgery. No patient was admitted to a hospital or have consulted within one month due to postoperative complications. No surgeryrelated complication underwent during the patients' follow-up. Conclusion: Our study highlights the safety and feasibility of VNS surgery in an outpatient setting for patients with severe intellectual disability. We report detailed protocol and preoperative checklist to optimize outpatient VNS surgery in these not able-bodied patients. Severe disabilities or epilepsy-associated handicaps should not be an exclusion criterion when considering ambulatory VNS implantation.