Social Cognitive Impairment in Early Parkinson's Disease: a novel "Mild Impairment"? - Sorbonne Université
Journal Articles Parkinsonism & Related Disorders Year : 2021

Social Cognitive Impairment in Early Parkinson's Disease: a novel "Mild Impairment"?

Abstract

Introduction Social cognition (SC) deficit has recently been described in the early stages of Parkinson's disease (PD), but findings remain unclear. Our objective was to determine the frequency of SC impairment in newly-diagnosed PD patients and whether it is independent of Mild Cognitive Impairment (MCI). Methods We enrolled 109 patients with idiopathic PD diagnosed within the previous four years (ICEBERG cohort) and 39 healthy participants. SC was evaluated using the Mini-Social Cognition and Emotional Assessment (Mini-SEA) that allows a multi-domain assessment of SC. Relationships between SC and clinical characteristics, global cognitive efficiency, mood, anxiety, apathy and impulse control disorders, were also evaluated. Results 30% of patients had significant socio-emotional impairment. Moreover, SC deficit in isolation was 3.5 times more frequent than MCI in isolation (20.2% vs 5.5% respectively). Both emotion identification and Theory of Mind were impaired compared to healthy participants. No effect of age, level of education, disease severity, dopamine replacement therapy, or global cognitive efficiency were found. Only scores on the Frontal Assessment Battery were correlated with SC abilities. Conclusion SC impairment is frequent in early PD and should be given more consideration. It often occurs in the absence of any other cognitive disorder and may represent the most common neuropsychological deficit in early-stage PD. In line with the definition of PD-MCI criteria, we consider the addition of a sixth MCI sub-type termed “Mild Social Cognition Impairment (MSCI)”. Further studies are required to validate the addition of this new MCI domain.
Fichier principal
Vignette du fichier
Czernecki et al. - 2021 - Social cognitive impairment in early Parkinson's d.pdf (348.63 Ko) Télécharger le fichier
Origin Files produced by the author(s)

Dates and versions

hal-03268496 , version 1 (23-06-2021)

Identifiers

Cite

Virginie Czernecki, Eve Benchetrit, Marion Houot, Fanny Pineau, Graziella Mangone, et al.. Social Cognitive Impairment in Early Parkinson's Disease: a novel "Mild Impairment"?. Parkinsonism & Related Disorders, 2021, 85, pp.117-121. ⟨10.1016/j.parkreldis.2021.02.023⟩. ⟨hal-03268496⟩
47 View
402 Download

Altmetric

Share

More