Vukičević and Gasperov introduced the concept of 148 discrete Adriatic indices in 2010. ese indices showed good predictive properties against the testing sets of the International Academy of Mathematical Chemistry. Among these indices, twenty indices were taken as beneficial predictors of physicochemical properties. e inverse sum indeg index denoted by ISI(G k) of G k is a notable predictor of total surface area for octane isomers and is presented as ISI(G k) = g k g k ′ ∈E(G k) (d G k (g k)d G k (g k ′)/d G k (g k) + d G k (g k ′)), where d G k (g k) represents the degree of g k ∈ V(G k). In this paper, we determine sharp bounds for ISI index of graph operations, including the Cartesian product, tensor product, strong product, composition, disjunction, symmetric difference, corona product, Indu-Bala product, union of graphs, double graph, and strong double graph.